Refrigerated and cold shipping

2° to 8° Celsius | 35° to 46° Fahrenheit


cold shipping box

Keeping products cold is critical for the healthcare and food industries. We provide reliable solutions for shipping breast milk, pharmaceuticals and perishables. Using cold packs, chilled boxes and other specialized containers provides the temperatures and security you need in order to meet cold shipping regulations and keep products in top condition.


Cold shipping boxes, packaging & containers

Our top priority is keeping your products cold. Each of the following packaging options is specially designed and tested to provide reliable cold temperatures during transit. If you’re packing cold shipments yourself, you can also find details on how to keep your cold shipments safe.

fedex temp assure boxes for cold shipping

Cold shipping package provided by FedEx

Cold shipping package provided by FedEx can keep your temperature-sensitive shipments between 2°C and 8°C (35°F and 46°F) for 48 or 96 hours* without the weight, hassle and expense of using dry ice or gel packs. 

*Actual cooling duration varies, depending on external temperatures.



These freight containers come in multiple sizes to help you send large shipments of clinical and pharmaceutical goods. The reusable containers can help you reduce costs while maintaining a safe environment for your products.


PharmaTherm by Intelsius

PharmaTherm packaging maintains cold temperatures for up to 120 hours. Developed specifically for pharmaceutical shipments, these boxes provide the temperatures you need in order to keep cold shipments safe during transit.


CSafe RKN and RAP

CSafe containers provide an active compressor solution that supports colder temperatures at 2°C to 8°C (35°F to 46°F) and 15°C to 25°C (59°F to 77°F). They are available in single pallet (RKN) or multi-pallet (RAP) sizes.

credo cube

Credo Cube™

These containers provide cold temperatures for up to five days. This extended protection can help reduce shipping costs or keep products safe during unexpected delays. The packaging is also reusable, allowing recipients to easily return products after initial delivery.


Envirotainer e1 & e2 - compressor

Envirotainer provides pallet-size containers with active compressor cooling and electric heating technology in RKN and RAP sizes. This helps maintain the temperatures needed to meet pharmaceutical industry requirements and easily move your products through the FedEx® shipping network.



Softbox provides customers with a single-pallet passive packaging solution with the ability to maintain temperature ranges of 2˚C to 8˚C (35°F to 46°F) and 15˚C to 25˚C (59°F to 77°F) for up to 120 hours.

Quality management/value-added services

Take advantage of the following services for increased visibility and protection of cold shipments.

FedEx Custom Critical®

Whether your priorities are visibility, security or compliance, our freight shipping experts can customize a cold shipping solution to meet your needs.This service is best used for healthcare shipments.

FedEx Priority Alert®

FedEx Priority Alert can monitor your cold shipments 24/7 and expedite them to help your contents arrive on time and in prime condition.

FedEx Cold Chain Centers

During delays, due to clearance or inclement weather, FedEx may route your cold shipments to a FedEx cold chain center. Contact your FedEx account representative to learn more. 

SenseAware®, a FedEx innovation

Monitor your cold shipments inside and out in real-time with SenseAware, or use it to validate your cold chain technologies.

FedEx Freight® Freezable Protection Service

If you’re shipping healthcare products with a freeze point at or below 0°C (32°F) between April and November, this service provides full product liability protection, up to the limits established in our FXF 100 Series Rules Tariff.